Vitamin D in Chronic Kidney Disease by Pablo A. Ureña Torres, Mario Cozzolino, Marc G. Vervloet

By Pablo A. Ureña Torres, Mario Cozzolino, Marc G. Vervloet

Vitamin D deficiency, circulating degrees less than 15 ng/ml, is a plague illness around the globe with greater than 1000000000 humans pain of it firstly of the 21-century. in addition to its impression on mineral and bone metabolism, those low nutrition D degrees also are linked to a variety of non-skeletal problems, between them heart problems, diabetes mellitus, a number of sclerosis, melanoma, tuberculosis, and immune procedure disorder. power Kidney sickness can also be a truly universal ailment, affecting greater than 10% of the area inhabitants, starting from level 1 to degree five ahead of dialysis. nearly 1% of the inhabitants in industrialized international locations is stricken by end-stage renal affliction (ESRD), wanting a renal substitute remedy both hemodialysis or peritoneal dialysis, and finally via renal transplantation. these CKD sufferers are extra at risk of express decreased nutrition D shares. for that reason, greater than 80 percentage of CKD sufferers have both inadequate or poor nutrition D degrees for a number of reasons.

Show description

Read Online or Download Vitamin D in Chronic Kidney Disease PDF

Best pulmonary & thoracic medicine books

Interstitial Pulmonary and Bronchiolar Disorders

Removal the guesswork linked to Interstitial Lung issues (ILDs) and bronchiolar problems, Interstitial Pulmonary and Bronchiolar issues addresses the problems confronted by means of pulmonologists in treating those problems. Divided into sections in line with the disorder sort (granulomatous, pneumonias, bronchiolar issues, vasculitis, and orphan lung disease), each one ailment is roofed from epidemiological, pathogenic, scientific, and radiographic views.

Idiopathic Pulmonary Fibrosis: Advances in Diagnostic Tools and Disease Management

From epidemiology and pathogenesis to sickness administration, this e-book stories our present figuring out of and offers up to date details of Idiopathic Pulmonary Fibrosis (IPF). A subtype of Idiopathic Interstitial Pneumonias (IIP), IPF is without doubt one of the so much elusive and intractable breathing illness to this point and its triggering elements stay doubtful.

Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide

This e-book is a state-of-the paintings assessment for clinicians and dieticians with an curiosity in meals and inflammatory bowel illnesses (Crohn’s illness, ulcerative colitis). the quantity covers new information approximately nutritional danger elements for Crohn’s illness and ulcerative colitis, examines the organization among nutrition and microbiome, describes many of the diets within the administration of those illnesses, and discusses macro- and micronutrient deficiency that happens in such sufferers.

The Frontal Sinus

This can be the one e-book devoted exclusively to frontal sinus issues. it's a richly illustrated and accomplished mine of data at the anatomy and administration of those problems. This up to date moment version deals a lot new details. extra subject matters contain balloon dilation, frontal surgical procedure as a part of cranium base surgical procedure, and advances in endoscopic strategies and instruments that experience happened given that 2004 and feature made open osteoplastic techniques nearly out of date.

Extra resources for Vitamin D in Chronic Kidney Disease

Example text

Am J Clin Nutr. 1983;37(3):403–6. 19. Evans RM, Mangelsdorf DJ. Nuclear receptors, RXR, and the Big Bang. Cell. 2014;157(1): 255–66. 20. St-Arnaud R, et al. Deficient mineralization of intramembranous bone in vitamin D-24hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. Endocrinology. 2000;141(7):2658–66. 21. Jones G, et al. Isolation and identification of 24-hydroxyvitamin D2 and 24,25-dihydroxyvitamin D2. Arch Biochem Biophys.

An additional factor, and potentially the major one, that contributes to decreased levels of 1,25(OH)2D in CKD is the progressive increase in the levels of FGF23 that occur early in the course of CKD. FGF23 directly suppresses the activity and expression of 1α-hydroxylase, and therefore, this is an important factor that contributes to the decreased ability of the failing kidney to maintain 1,25(OH)2D production. In addition, FGF23 is also known to increase the expression of 24-hydroxylase, which is the enzyme responsible for the degradation of 1,25(OH)2D.

2, reprinted from [3]). This study also found that mean 25(OH)D values were lower in the institutionalized than non-institutionalized elderly, especially in Europe and the Asia/Pacific region. 2 Estimated mean circulating 25(OH) vitamin D levels (in ng/ml) (95 % confidence intervals) according to age and region, from the meta-analysis of Hilger et al. 9) 6 6 4 1,913 2,079 874 See also Fig. 3). Although cutaneous synthesis is the main source of vitamin D, it may also come from diet, notably from fatty fish, fish oils, fortified dairy products or fruit juices, and vitamin supplements.

Download PDF sample

Rated 4.15 of 5 – based on 33 votes