By Mano J. Thubrikar
The function of the publication is to convey the 2 disciplines - vascular mechanics and pathology - jointly. furthermore, the ebook bridges the space in our wisdom and complements engineering functions in medication. This state-of-the-art paintings provides using veins as arterial grafts and discusses the function of vein valves in graft stenosis. The booklet illustrates aneurysm formation, progress, and rupture, utilizing strain vessel rules. This new paintings information the research of, among different subject matters, aortic dissection, exhibiting for the 1st time that the aortic root mechanics performs an important position within the improvement of this pathology.
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Volume 1. Lippincott-Raven Publishers, Philadelphia, 1996:597. 2 Atherosclerosis II 1. Anatomical Distribution of Atherosclerosis . . . . . . . . . . . . 1. Atherosclerosis and Functions of the Artery. . . . . . . . . 2. Stress-Concentration at the Arterial Branch Origins . . . . . . 22 2. Atherosclerosis and Stress-Concentration . . . . . . . . . . . . 1. Ostial Lesions and Stress-Concentration . . . . . . . . . . 2. Aortic Arch Lesions and Stress/Strain Concentration .
3. Distribution of strain around the ostium of a bovine circumflex coronary arterial branch. Experimentally measured strains near both the distal and the proximal lips of the ostium are as high as 5% to 7%, whereas those away from the ostium are 2% to 3%. The analytic strains were obtained from finite element analysis. The strains are for the pressure increase from 80 to 120 mmHg. 24 2. Atherosclerosis II The increase in intravascular pressure from 80 to 120 mmHg produced the stretch of 5–7% in the branch region and only of 2–3% in other regions (11).
This aspect of flow division was known to the medical community also. Therefore, it made sense to consider that flow separation, turbulence, high shear, low shear, and so forth, is somehow responsible for localization of the disease. The flow is in direct contact with the endothelial cells (ECs), and therefore it would be natural to explore the role of ECs in atherosclerosis. This approach is even more convincing when we consider that the atherosclerotic lesions always involve the intima. So, for the most part, the research path has been flow separation–EC–atherosclerosis.