By Howard R. Garis
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Extra resources for Uncle Wiggily and the Canoe
R. W. MILLER, and J. SCOTTO: U. S. childhood cancer mortality patterns, 1950-1959. Etiologic implications. J. Amer. med. Ass. 192,593-596 (1965). 35. DAVIES, J. N. : Lymphomas and leukemias in Uganda Africans. In ROULET, F. : Op. Cit. Ref. 10, p. 67-69. 36. : Lymphomas of African children with different forms or environmental influences. J. Amer. med. Ass. 181, 1026-1928 (1962). 37. , C. A. LINSELL, F. E. BARNHART, and R. MARTYN: An epidemiologic approach to the lymphomas of African children and Burkitt's sarcoma of the jaws.
With adequate treatment with methotrexate in the early cases or with cyclophosphamide in the more advanced and late stages it appears that about 20 0/0 may hope to be freed of disease for a long period if not completely cured. In successfully treated cases the tumours disappear in the first fourteen days of treatment. Occasionally spontaneous regression takes place or response may be noted to inadequate chemotherapy suggesting some sort of immune reaction and in keeping with this the use of serum from cured patients may cause partial regression in affected children .
Pallor and lassitude are much the commonest presenting symptoms, occurring in about 70-80 0 /0 of patients. Purpura, either in the form of petechial haemorrhages, bruising, or haemorrhage from nose or mouth, occurs in about one third to one half of the cases at the time of onset. Enlargement of lymph nodes as a presenting symptom is less common, perhaps 25010 of cases, although it is found more frequently as a sign on physical examination. Other presenting symptoms include fever of unexplained origin, limb pains, more often in bones than in joints, and sore throat.