Topics in Current Chemistry 197, Dendrimers by Fritz Vogtle (Editor)

By Fritz Vogtle (Editor)

Dendrimers are a category of hugely branched molecules that mix the houses of polymers and small discrete molecules. One categorized one of the unique molecules of chemistry, dendrimers have attracted significant realization lately, as their detailed host/guest homes and their potential of being functionalized within the outer edge to boot within the center have resulted in new fabrics with a good capability for purposes. This quantity provides the nation of artwork during this blossoming region, written by way of pioneers within the fields. masking the factitious, supramolecular, stereochemical, host/guest and polymer chemistry of dendritic and hyperbranched molecules, this quantity explains either theoretical and functional features, together with chirality reactivity, mechanism, fabric houses and organic relevance.

Show description

Read Online or Download Topics in Current Chemistry 197, Dendrimers PDF

Best chemistry books

Opioid Analgesics: Chemistry and Receptors

The swiftly burgeoning learn of the earlier twenty years on agonist-antagonist analgesics and opioid receptors makes this exhaustive evaluate of opioid anal­ gesics rather suitable and well timed. After an introductory bankruptcy the extra 12 chapters commence logically with morphine and congeners (4- epoxymorphinans) and finish with opioid receptors.

Additional resources for Topics in Current Chemistry 197, Dendrimers

Sample text

This procedure eventually led to DSM’s commercially available poly(propylene imine) dendrimers. The addition of ammonia to excess methyl acrylate (a linear monomer), followed by amidation with excess ethylenediamine afforded the resultant cascade molecule, and thus Tomalia [37] created the commercially available PAMAM starburst series of dendrimers (2, Fig. 2). Related core molecules such as ethylenediamine and aminoalcohols and other functionalizable groups such as thiol moieties were used to prepare similar dendrimers [38].

Such non-covalent interactions [89] have attracted synthetic chemists to construct receptors capable of binding to biologically-important as well as interesting unnatural molecules. 28 29 Fig. 13. , 28) containing 2,6-diacylaminopyridine H-bonding units (Fig. 13). 1H-NMR titration was used to evaluate host-guest interactions with complementary guests such as glutarimide, barbituric acids as well as the drug AZT. The findings supported discrete host-guest interactions, although, for the higher generation dendritic hosts, it was complicated by the fact that guest molecules could bind at alternate, albeit weaker H-bonding sites within the host’s infrastructure [91].

These fractal-like constructs generally possess excellent solubilities, when compared to “classical” polymers, which therefore facilitate their purification and characterization. It should be noted that the unique three-dimensional, branched structure and the nature of the peripheral functional groups are important factors that determine the chemico-physical Fig. 1. Linear vs. V. R. Newkome properties of these cascade molecules. Additionally, dendritic polymers in general possess low intrinsic viscosities when compared to their linear counterparts.

Download PDF sample

Rated 4.81 of 5 – based on 42 votes