By Franz Paul Probst M. D. (auth.)
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Extra info for The Prosencephalies: Morphology, Neuroradiological Appearances and Differential Diagnosis
Splenium-like posterior termination of the white-matter midline bridge. (Courtesy of Lichtenstein and Maloney, and the 1. Neuropathol. Exp. ) 42 Cytoarchitecture Gross and Kaltenback also commented on the antero-posterior gradient of development and particularly on the pseudo-splenium. In their highly differentiated specimen the posterior part of the white matter bridge across the midline was continuous with the alveus of the hippocampi and this was also true of the other brains mentioned above.
Myelination is another aspect of maturation. Delayed myelination has almost invariably been encountered in the brains of stillborn or short-lived infants with brains of low differentiation, and many examples of this could be cited. Yakovlev's fmdings suggest in general an anterior-posterior gradient of 'hemispheric' development. This gradient, clearly recog- nizable in the specimens of lowest development, increases with differentiation according to the potential available to be 'consumed' during development, and the tendency to mimic nonnal brains is obvious.
It is evident from this case that air filling of the ventricles via the lumbar route would probably have been unsuccessful. Craniofacial and Extracranial Malformations In the early days, Ernst mentioned a number of somatic dysplasias, observed in association with these malformations, such as agnathia, synotia and other ear deformities of various types, microstomia, diastematomyelia, spina bifida, cardiac septal defects, malformations of the great vessels, diaphrag~ matic hernia and polydactylies.