Proteoglycans in Lung Disease (Lung Biology in Health and by Hari G. Garg

By Hari G. Garg

Discusses new remedy options for malignant mesothelioma, pulmonary edema, fibrosis, bronchial asthma, emphysema, and bronchiectasis.Proteoglycans in Lung disorder considersglycosaminoglycans as novel healing brokers or pursuits in lung ailment the position of proteoglycans in choosing mechanical habit of lung tissue hyaluronan and its receptors in wound therapeutic, irritation, vasculogenesis, and angiogenesis the effect of small proteoglycans on matrix meeting versican as a modulator of telephone adhesion, migration, and proliferation antiproliferative task of heparin and its derivatives on pulmonary artery soft muscle cells the consequences of mechanical pressure on proteoglycans the services of proteoglycans within the vascular wall the impact of hypoxia on glycosaminoglycans within the lung created from greater than 1940 references, Proteoglycans in Lung ailment

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In the embryo it is thought to play a role in influencing cell migration and interaction during organogenesis. It might play a similar role during wound healing and in fibrosis. 3. Link Protein The interaction between the aggregating proteoglycans and HA is noncovalent and potentially reversible, which could have dire consequences for the tissue. In vivo, undesired dissociation is prevented by a link protein that interacts with both the G1 region of the hyalectan and HA (34). In some respects the link protein may be considered the smallest member of the hyalectan family, as it is structur- Proteoglycans of the Lung 9 ally similar at both the protein and gene organization levels to the G1 region (35).

Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol 1999; 147:1109–1122. Arikava-Hirasawa E, Watanabe H, Takami H, Hassell JR, Yamada Y. Perlecan is essential for cartilage and cephalic development. Nat Genet 1999; 23:354–358. Nicole S, Davoine CS, Topaloglu H, Cattolico L, Barral D, Beighton P, Ben Hamida C, Hammouda H, Cruaud C, White PS, Samson D, Urtizberea JA, Lehmann-Horn F, Weissenbach J, Hentati F, Fontaine B. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia).

Tapanadechopone P, Hassell JR, Rigatti B, Couchman JR. Localization of glycosaminoglycan substitution sites on domain V of mouse perlecan. Biochem Biophys Res Commun 1999; 265:680–690. SundarRaj N, Fite D, Ledbetter S, Chakravarti S, Hassell JR. Perlecan is a component of cartilage matrix and promotes chondrocyte attachment. J Cell Sci 1995; 108: 2663–2672. Iozzo RV, Cohen IR, Gra¨ssel S, Murdoch AD. The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices.

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