Protein Targeting to Mitochondria by E. Edward Bittar (Eds.)

By E. Edward Bittar (Eds.)

A number of newly-synthesized polypeptides needs to move one or a number of intracellular membranes to arrive their practical destinations within the eukaryotic phone. The mechanisms of protein trafficking, particularly the post-translational focusing on and membrane translocation of proteins, are of basic organic value and are the focal point of extensive study world-wide. For greater than 15 years, mitochondria have served because the paradigm organelle method to review those procedures. even supposing key questions, comparable to how accurately proteins move a membrane, nonetheless stay to be spoke back, interesting growth has been made in realizing the fundamental pathways of protein import into mitochondria and the parts concerned. as well as a desirable richness and complexity intimately, the research of mitochondrial protein import has published mechanistic rules of normal value: significant discoveries contain the demonstration of the requirement of an spread out nation for translocation and of the fundamental position of molecular chaperones on either side of the membranes in keeping a translocation-competent conformation and in protein folding after import. it really is changing into transparent how a polypeptide chain is "reeled" around the membrane in an ATP-dependent approach by way of the useful cooperation of membrane proteins, most likely constituting a part of a transmembrane channel, with peripheral parts on the trans-side of the membrane. during this quantity, eminent specialists within the box make the effort to check the critical features of mitochondrial biogenesis. The logical order of the sixteen chapters depends upon the series of steps in the course of protein import, beginning with the occasions occurring within the cytosol, by means of the popularity of concentrating on signs, the translocation of precursor proteins around the outer and internal membranes, their proteolytic processing and intramitochondrial sorting, and eventually their folding and oligomeric meeting. additionally, the mechanisms concerned with the export of mitochondrially encoded proteins in addition to fresh advances in realizing the department and inheritance of mitochondria should be mentioned.

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REFERENCES Amberg, D. , Goldstein, A. , & Cole, C. N. (1992). Isolation and characterization of RATI: An essential gene of Succhummyces cerevisiae required for the efficient nucleocytoplasmictrafficking of mRNA. Genes Dev. 6,1173-1 189. , & Trachsel, H. (1993). Regulation of translation initiation and modulation of cellular physiology. Trends Biochem. Sci. M32. Protein Transport into Mitochondria 29 Attencio, D. , & Yaffe, M. P. (1992). M A S , a yeast homologue of DnaJ involved in mitochondrial protein import.

43 Advances in Molecular and Cell Biology, Volume 17, pages 3349. Copyright 0 1996 by JAI Press Inc. All rights of reproduction in any form reserved. ISBN: 0-7623-0144-9 33 34 KATSUYOSHI MIHARA and TSUNEO OMURA H. Binding of the MSF-Precursor Complex to the Outer Mitochondria1 Membrane . . . . . . . . . . . I. Molecular Properties of MSF Subunits . . . . . . . . . . V Presequence-binding Cytosolic Factors in Mitochondrial Protein Import . . References .

15, 68844894. , & Georgopoulos, C. (1989). Initiation of h DNA replication with purified host and bacteriophage encoded proteins: The role ofthednaK, dnaJ, andgrpE heat shock proteins. EMBO J. 8,1601-1608. PRESEQUENCE BINDING PROTEINS AS CYTOSOL‘IC IMPORT-STIMULATlON FACTORS IN MITOCHONDRIAL PROTEIN IMPORT Katsuyoshi Mihara and Tsuneo Omura I. Introduction . . . . . . . . . . . . . . . . . . 3 4 11. “Targeting Factor” of Rabbit Reticulocyte Lysate . . . . . . . . 35 111.

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