Pharmacology and Therapeutics of Asthma and COPD by Clive P. Page, Peter J. Barnes

By Clive P. Page, Peter J. Barnes

The current quantity is meant to be a huge reference source for chest physicians and people occupied with the improvement of novel pharmaceutical entities for those ailments. across the world famous experts overview crucial new details at the advances in our realizing of the pathogenesis and therapy of those illnesses, together with the gigantic advances within the topical supply of inhaled drugs. every one bankruptcy is widely referenced, generously illustrated with transparent diagrams and pictures, and represents a cutting-edge evaluation of this crucial zone of respiration medicine.

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2011). Moreover, cholinergic parasympathetic tone contributes to contraction of bronchial smooth muscle and narrowing of the airways in asthmatic patients. The extent to which increased parasympathetic tone is a consequence of reflex to the inflammatory state or is a pathophysiological mechanism in itself is unclear. Regardless, the raised parasympathetic tone does provide a rationale for the use of antimuscarinic agents in asthma (Price et al. 2014). 1 COPD There are currently six muscarinic receptor antagonists licenced for use in the treatment of COPD, the short-acting muscarinic receptor antagonists (SAMAs) ipratropium bromide and oxitropium bromide and the long-acting muscarinic receptor antagonists (LAMAs) aclidinium bromide, tiotropium bromide, glycopyrronium bromide and umeclidinium bromide.

Thus, monotherapy β2 agonists may fall short (and lack safety) for effective asthma control in all but patients with very mild disease when as required SABA usage is acceptable. Whether concomitant treatment with ICS addresses the possible neutral or pro-inflammatory effects of β2 agonists is not clear. Of note, the black box warnings exist for combined (LABA + ICS) therapy as well, suggesting that sufficient evidence of ICS addressing the LABA safety concern does not yet exist. b2 Agonists 5 35 Pharmacogenetics and the b2AR Pharmacogenetics is a term referring to the study of genetic factors on efficacy and side effect profiles of drugs.

2 LAMA/ICS Combination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 LAMA/LABA/ICS Combination . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 LAMA/PDE4 Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 LAMA Compounds in Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . .

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