By John M. Kirkwood
Facilitating efforts to avoid cancer development, this up to date reference provides the newest advances within the pathology, molecular biology, and treatment of cancer in early, high-risk, and complicated phases. Discusses development elements, cytokines, receptors, oncogenes, tumor suppressor genes, adhesion molecules, and proteases in cancer and examines the best use of interferon adjuvant treatment! Written via best specialists from the U.S. and Europe, Molecular analysis and remedy of cancer · information the preclinical and medical foundation for brand new vaccines in response to gangliosides and peptides · explains the jobs of chemotherapy and radiosurgery · studies the molecular positive factors of cancer and precursor cells · describes the occasions thinking about induction and upkeep of antitumor T-cell reaction and numerous get away mechanisms from immune reputation · analyzes melanotic and dysplastic nevi · explores the opportunity of vaccines that result in antibodies in immunotherapy and vaccines in high-risk cancer · summarizes cytotoxic chemotherapy in treating metastatic cancer · elucidates whole-brain radiotherapy, surgical resection, and stereotactic radiosurgery in dealing with cancer mind metastasis · and extra! Containing key bibliographic citations for extra in-depth research of specific subject matters, Molecular prognosis and therapy of cancer is a superb source for oncologists, dermatologists, molecular and phone biologists, immunologists, pathologists, pharmacologists, toxicologists, interns, citizens, fellows, and graduate and scientific university scholars in those disciplines.
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Cell Growth & Differentation. In press. 53. Denton KJ, Stretch JR, Gatter KC, Harris AL. A study of adhesion molecules as markers of progression in malignant melanoma. J Pathol 1992; 167:187191. 54. Kageshita T, Yoshii A, Kimura T, Kuriya N, Ono T, Tsujisaki M, Imai K, Ferrone S. Clinical relevance of I-CAM-1 expression in primary lesions and serum of patients with malignant melanoma. Cancer Res 1993; 53:49274932. 55. van Duinen CM, van den Broek LJ, Vermeer BJ, Fleuren GJ, Bruijn JA. The distribution of cellular adhesion molecules in pigmented skin lesions.
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Thierry Boon et al. developed a method to overcome this limitation by cloning the genes encoding antigens recognized by tumor-specific CTL clones (49). This technique is based on two crucial processes. The first is to transfect a complementary DNA library derived from the tumor into either antigen loss variants of the same tumor or Cos cells together with genes encoding the appropriate MHC class I. The second was to identify the antigen in CTL stimulation assays.