Micro-Segmented Flow: Applications in Chemistry and Biology by Brian P. Cahill (auth.), J. Michael Köhler, Brian P. Cahill

By Brian P. Cahill (auth.), J. Michael Köhler, Brian P. Cahill (eds.)

The e-book is devoted to the tactic and alertness strength of micro segmented move. the hot nation of improvement of this strong procedure is gifted in 12 chapters through top researchers from diversified international locations. within the first part, the foundations of new release and manipulation of micro-fluidic segments are defined. within the moment part, the micro continuous-flow synthesis of alternative kinds of nanomaterials is proven as a customary instance for using merits of the method in chemistry. within the 3rd half, the actual value of the strategy in biotechnical purposes is gifted demonstrating the development for miniaturized cell-free approaches, for molecular biology and DNA-based diagnostics and sequencing in addition to for the advance of antibiotics and the overview of poisonous results in drugs and environment.

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Extra resources for Micro-Segmented Flow: Applications in Chemistry and Biology

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This can lead to any droplet being removed from the array, for example to keep the X shape in the final state Sect. 2, focusing the laser on a particular droplet can be used to remove it from its anchor. This is shown in Fig. 9, where a series of drops is initially trapped in a regular array. Then by positioning the laser at particular locations in the array, selected drops can be extracted. These operations can be applied in order to selectively recover certain drops, depending on their contents, or in order to free up certain anchor sites for new drops to be captured.

The general philosophy was to rely on the passive behavior of the microchannel design for most operations and to use the laser forcing as a localized perturbation that pushes the drop past an energetic barrier, from one state to another. Indeed, such an optical setup had already been used to control droplet motion in linear or quasi-linear channels, in addition to forcing their fusion [10, 39, 41, 42]. Similar operations have also been demonstrated for drops outside microchannels by Faris and coworkers [4, 43].

G. perfluorodecalin, is a typical example of this strategy 34 M. Budden et al. for formation of liquid micro compartments. Droplets and segments can be separated from each other by gas bubbles or by a carrier liquid. Both types of compartments can be realized over a large range of volumes reaching typically from microliters down to picoliters or even femtoliters. This corresponds to liquid compartments between millimeter and micrometer size. The deciding difference between both types is not given by the individual volume but by the relation to a wall, a guiding channel or interface.

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