Metallopharmaceuticals II: Diagnosis and Therapy by Michael F. Tweedle, Krishan Kumar (auth.), Professor Michael

By Michael F. Tweedle, Krishan Kumar (auth.), Professor Michael J. Clarke, Professor Peter J. Sadler (eds.)

Inorganic compounds supply a lot scope for the layout of novel and healing brokers. The common use of paramagnetic steel complexes as powerful distinction brokers for magentic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals will be finely managed through the approriate collection of ligands. The succcessful focusing on of radioisotopes back is dependent upon ligand layout and steel oxidation kingdom. Bismuth and gold complexes have lengthy been utilized in medication yet just recently have advances been made in figuring out the molecular foundation in their mechanism of motion. New components with scientific power comprise using polyoxometallates and fullerenes as antiviral brokers and vanadium complexes as insulin mimetics.

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This will dramatically restrict new developments, especially in gadolinium chelates. However, this problem can be addressed, in principle, by developing chelates with greater relaxivity, and creating oligomers of these [130]. The work toward optimizing relaxivity is currently aimed at small improvements in the existing gadolinium chelates as relaxation agents, but the larger goal is to endow the field of MRI with a set of injectable pharmaceuticals that will serve the same function that 99mTc pharmaceuticals serve in nuclear medicine.

Nunn A, Linder K, Strauss HW (1995) Eur J Nucl Med 22:265 10. a) Breeman WAP, Hofland LJ, Bakker WH et al. (1993) Eur J Nucl Med 20:1089; b) Fishman AJ, Picke MC, Kroon D, Fucello Ai, Rexinger D, Ten Kate C, Wilkinson A, Rubin RH, Strauss HW (1991) J Nucl Med 32:483 11. a) Bloch F (1946) Phys Rev 70:460; b) Purcell EM, Torrey HG, Pound TV (1946) Phys Rev 69:37 12. Martin GE, Zekter AS (1988) Two Dimensional Methods Establishing Molecular Connectivity. VCH, New York, NY 13. Bloch F, Hansen W, Packard M (1948) Phys Rev 70:474 14.

F. Tweedle, K. Kumar Fig. 19. Examples of Magnetic Resonance Angiography (MRA). A Ti weighted MRA images using AMI 227. Left: unenhanced. Right: after administration of AMI 227. Courtesy of Dr. S. McLachlan and Ms. M. Morris, Advanced Magnetics, Inc. 05 mmol Gd/kg) that binds human serum albumin on injection, rendering greater relaxivity in blood than in extracellular space . From Grist TM, Korosec FR, Peters DC, Witte S, Walovitch RC, Dolan RP, Bridson WE, Yucel EK, Mistretta CA , Radiology, 1998, 207:539-544.

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