Lung Injury: Mechanisms, Pathophysiology, and Therapy by Robert H. Notter, Jacob Finkelstein, Bruce Holm

By Robert H. Notter, Jacob Finkelstein, Bruce Holm

Progressing from normal medical rules and ideas to in-depth topical discussions of present learn and remedy equipment, this entire reference defines the mobile and molecular mechanisms contributing to inflammatory lung harm and service. huge insurance is equipped on key mediators and pathways vital in acute and persistent pulmonary irritation and lung harm, in addition to the mechanistic pathophysiology of comparable illnesses starting from scientific acute lung damage (ALI) and the extreme respiration misery syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and different subacute and protracted stipulations. extra chapters additionally tackle vascular disorder, surfactant disorder, reactive oxygen/nitrogen species, and phone and animal types of acute and persistent lung harm.

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36. Strieter RM. Mechanisms of pulmonary fibrosis. Chest 2001; 120 (suppl): 77S–85S. Introduction to lung injury 13 37. Katzenstein AL, Myers JL. Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med 1998; 157:1301–1315. 38. Finkelstein JN, Horowitz S, Sinkin RA, Ryan RM. Cellular and molecular responses to lung injury in relation to induction of tissue repair and fibrosis . Clin Perinatol 1992; 19:603–620. 39. Sime PJ, O’Reilly KMA. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.

During alveolarization (see Fig. 2), alveoli develop in a centripetal manner initially from saccules, then on respiratory bronchioles and, from 4 years onwards on terminal bronchioles (167). Most knowledge about postnatal lung development has been obtained from animal studies, in particular the rat (3,168). Postnatal lung growth in rats can be divided into four stages. Initially a phase of expansion (birth-4 days) occurs, during which lung growth lags behind the increase in body weight and lungs enlarge primarily by expansion.

16. Taussig LM, Landau LI, Le Souef PN, Morgan WJ, Martinez FD, Sly PDE. Pediatric Respiratory Medicine. St. Louis: Mosby,1999. 17. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342:1334–1348. 18. Fishman AP, Elias JA, Fishman JA, Gripp M A, Kaiser LR, Senior RM. Fishman’s Pulmonary Diseases and Disorders. 3rd ed. New York: McGraw-Hill, 1998. 19. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds. Harrison’s Principles of Internal Medicine.

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