Liver Metastases: Biology, Diagnosis and Treatment by Martin A. Adson (auth.), Dr. O. J. Garden, Dr. J. G.

By Martin A. Adson (auth.), Dr. O. J. Garden, Dr. J. G. Geraghty, Dr. D. M. Nagorney, Dr. R. A. Audisio, Dr. H. S. Stoldt (eds.)

Liver Metastasis: Biology, prognosis and Treatment deals a accomplished evaluate of liver metastasis by means of delivering a suite of pivotal contributions from a global college. quite a lot of issues are awarded, with every one contributor targeting his personal strong point to supply the newest suggestions in addition to beneficial insights in line with a wealth of expertise. Epidemiological and organic facets are mentioned, diagnostic and staging difficulties are said, and all remedy modalities are analysed together with gene remedy, immunotherapy and palliative care. the traditional methods to prognosis and treatment are tested while new and destiny traits are mentioned on and explored. Of curiosity to either experts and postgraduates within the fields of oncology and gastroenterology this publication may also be of curiosity to researchers in inner medicine.

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In culture, however, KM20 and KM12C cells produced similar levels of CEA mRNA and protein. The level of CEA in the serum of patients with colorectal carcinoma is influenced by the balance between production of CEA by tumour cells and the ability of the liver to clear CEA from the blood. 96 Our data do not address this possibility but show that CEA expression is indeed regulated by cell density. When cells enter quiescence, they can exhibit major alterations in cell surface receptors, expression of transcription factors, enzymes and cellular ultrastructure.

Radinsky R. Paracrine growth regulation of human colon carcinoma organ-specific metastases. Cancer Metastasis Rev 1993; 12:345-361. 14. Radinsky R, Risin S, Fan D, Dong Z, Bielenberg D, Bucana CD, Fidler lJ. Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clin Cancer Res 1995; 1:19-31. 15. Radinsky R. Modulation of tumor cell gene expression and phenotype by the organ-specific metasatatic environment. Cancer Metastasis Rev 1995; 14:323-338.

89. Barbera-Guillem E, Smith I, Weiss 1. Cancer-cell traffic in the liver. I. Growth kinetics of cancer cells after portal-vein delivery. Int J Cancer 1992; 52:974-977. 90. Coulombe J, Pelletier G. Gangliosides and organ-specific metastatic colonization. Int J Cancer 1993; 53:104-109. Liver Metastases 91. Fujita S, Suzuki H, Kinoshita M, Hirohashi S.

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