By Barbara J. Bain(auth.)
UP-TO-DATE useful consultant TO LEUKAEMIA DIAGNOSIS
Written via a popular professional this sensible advisor have been totally revised and up-to-date. The publication covers fresh advances within the fields of immunophenotyping, cytogenetics and molecular genetics. It illustrates how laboratory innovations are used for the prognosis and class of leukaemia and comprises pictures of irregular cells to assist analysis.
This fourth variation:
- Incorporates the techniques of the 2008 WHO class of Tumours of Haematopoietic and Lymphoid Tissues
- Includes three hundred prime quality complete color electronic pictures of irregular cells in leukaemia and lymphoma - 50 of that are thoroughly new
each haematologist and haematopathologist may still make a copy shut to hand for fast reference.Content:
Chapter One the character of Leukaemia, Cytology, Cytochemistry and the FAB class of Acute Leukaemia (pages 1–63):
Chapter Immunophenotyping and Cytogenetic/Molecular Genetic research in Leukaemia and similar stipulations (pages 64–113):
Chapter 3 Acute Leukaemia: Integration of Morphological, Immunophenotypic and Genetic details and the WHO category (pages 114–218):
Chapter 4 The Myelodysplastic Syndromes (pages 219–260):
Chapter 5 continual Myeloid Leukaemias (pages 261–300):
Chapter Six Lymphoid Leukaemias of Mature T, B and typical Killer Cells (pages 301–376):
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Extra resources for Leukaemia Diagnosis, Fourth Edition
Clinical correlates of FAB categories of acute lymphoblastic leukaemia Many cases of L3 ‘ALL’ represent Burkitt lymphoma and the cytological features are important in suggesting this diagnosis. However, the categorization of a case as L1 or L2 ALL is of little importance. The FAB L1 category includes more childhood cases with a relatively good prognosis. The incidence of L1 ALL falls with increasing age whereas the incidence of L2 ALL does not vary much with age. L2 ALL has generally been found to have a worse prognosis, although the difference is not major.
59 Ultrastructure of lymphoblasts in FAB L1 ALL. ) numbers of azurophilic, but peroxidase-negative, granules. 62. About a quarter of cases of ALL fall into the L2 category. L2 ALL may be of B or T lineage. Fig. 60 BM film from a patient with FAB L2 ALL showing large pleomorphic blasts; the cells were CD10 positive. MGG ×100. abundant. The nuclei are irregular in shape with clefting, folding and indentation being common, and with heterogeneity also of the chromatin pattern. Nucleoli are usually present and may be large.
23). qxd 24 15/1/10 20:20 Page 24 CHAPTER 1 (b) Fig. 22 (a) PB film and (b) film of cultured leukaemic cells from a patient with FAB M3 variant AML showing the acquisition of granules on culture. MGG ×100. ) (a) Fig. 23 (a) PB film of a patient with FAB M3 variant AML showing cells with bilobed and reniform nuclei and sparse, fine granules. One binucleate cell is present and another cell is characterized by basophilic cytoplasm and cytoplasmic projections. MGG ×100. (a) the same staining characteristics as primary granules.