Introduction to Drug Metabolism by G. Gordon Gibson PhD, Paul Skett Fil.dr. (auth.)

By G. Gordon Gibson PhD, Paul Skett Fil.dr. (auth.)

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Extra resources for Introduction to Drug Metabolism

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And Tester B. (1980) Concepts in drug metabolism, Marcel Dekker, New York. W. (1983) Drug metabolism and distribution, Elsevier, Amsterdam. J. (ed) (1990) Conjugation reactions in drug metabolism, Taylor and Francis, London. V. V. L. T. (1959) Detoxification mechanisms, Chapman and Hall, London. R. (1977) Metabolism of endogenous substrates by microsomes, Drug Metab. , 6 155-212. Burchell, B. H. (1989) UDP-Giucuronosyltransferases. Pharmacal. , 43 261-89. H. eta/. (1992) Cytochrome P450 and the arachidonate cascade.

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The ever increasing number of cytochrome P450 sequences has also stimulated computer-based molecular modelling of their tertiary structures. This modelling has been facilitated by the crystallisation and X-ray crystal structure determination of the soluble cytochrome P450 from the soil bacterium Pseudomonas putida (termed cytochrome P450101 in the new gene nomenclature and cytochrome P450cam in the old nomenclature). Thus, by using cytochrome P450101 as a 'template', other cytochrome P450s can be modelled based on sequence similarities.

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