Inhibitory Regulation of Excitatory Neurotransmission by Mark G. Darlison

By Mark G. Darlison

Darlison’s very good paintings experiences points of GABA-A receptor functionality, in addition to the houses of a number of different very important inhibitory proteins, equivalent to GABA-C receptors and G-protein coupled receptors together with neuropeptides. Glycine receptors and potassium channels are lined too. the implications of mutations that disrupt the legislation of excitatory neurotransmission, and efforts to focus on the GABAergic method for healing gain, also are discussed.

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Additional resources for Inhibitory Regulation of Excitatory Neurotransmission (Results and Problems in Cell Differentiation) (Results and Problems in Cell Differentiation)

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2002). Recently, HAP1 was identified in a yeast two-hybrid screen as a binding partner for the β1 subunit, and its interaction with β1–3 subunit isoforms was established using pulldown and coimmunoprecipitation experiments (Kittler et al. 2004). In hippocampal neuronal cultures, HAP1 is colocalized with GABAA receptors and promotes receptor recycling, thus increasing mIPSC amplitude and synaptic inhibition. Concomitant with enhanced recycling is a decrease in receptor degradation, suggesting a role for HAP1 in the postendocytic sorting of GABAA receptors.

Proc Natl Acad Sci USA 101:12736–12741 Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo IL, Jovanovic JN, Pangalos MN, Haucke V, Yan Z, Moss SJ (2005) Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci USA 102:14871–14876 Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM (2000) The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.

This internalization is prevented by hypertonic sucrose, a treatment known to inhibit GABAA receptor endocytosis (Kittler et al. 2000). Interestingly, insulin, a hormone that promotes GABAA receptor insertion into the plasma membrane (Wan et al. 1997), blocks the decrease in receptor surface expression while exerting a protective effect against not only OGD, but also glutamate-induced toxicity (Mielke and Wang 2005). 5 Conclusions It is an exciting time for GABAA receptor trafficking research. Several proteins have been identified within the secretory pathway that appear to be involved in receptor cell surface trafficking.

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