Gaba and the Basal Ganglia: From Molecules to Systems by James M. Tepper, Elizabeth D. Abercrombie and J. Paul Bolam

By James M. Tepper, Elizabeth D. Abercrombie and J. Paul Bolam (Eds.)

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Biochem. , 68: 1621–1629. , Kobayashi, K. and Kobayashi, K. (2004) Identification of GABAA receptor subunit variants in midbrain dopaminergic neurons. J. , 89: 7–14. J. and Wallner, M. (2004) Fishing for allosteric sites on GABA(A) receptors. Biochem. , 68: 1675–1684. T. K. (1990) GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. , 3: 59–76. W. R. (2002) GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain.

Wisden, W. and Sieghart, W. (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochem. , 68: 1621–1629. , Kobayashi, K. and Kobayashi, K. (2004) Identification of GABAA receptor subunit variants in midbrain dopaminergic neurons. J. , 89: 7–14. J. and Wallner, M. (2004) Fishing for allosteric sites on GABA(A) receptors. Biochem. , 68: 1675–1684. T. K. (1990) GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system.

2004, 2005). , 2003). , 2005). , 1999). New subtype-selective drugs for GABAA receptors GABAA receptors have always been fertile ground for drug companies. Benzodiazepines, although for many years the main stay of clinical treatments for anxiety disorders, fell out of favour to selective serotonin reuptake inhibitors (SSRIs) due to sideeffects like sedation, cognitive impairment and abuse liability. But SSRIs are too slow acting for some situations, requiring several weeks to work. Thus there is a medical need for fast-acting anxiolytics with few/no side-effects (Whiting, 2006).

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