Q&A for the USMLE Step 1 by Tao Le

By Tao Le

1,000 questions and solutions organize you for the USMLE Step 1!

The in basic terms complete Q&A assessment for the USMLE Step at once associated with high-yield proof from Dr. Le's First relief for the USMLE Step 1, this crucial examine advisor bargains one thousand board-style questions and solutions, easy-to-navigate, excessive yield factors for proper and mistaken solutions, and greater than 350 accompanying images.


  • a thousand board-style questions and solutions -- reviewed and authorized -- by means of scholars who simply aced the examination
  • specified reasons for either correct and unsuitable solutions - with letter ideas in boldface for at-a-glance overview
  • Chapters keyed to Dr. Le's First relief for the USMLE Step 1 so that you can concurrently evaluation questions and high-yield proof
  • one hundred thirty+ high-yield photos, diagrams, and tables
  • One whole perform examination including 7 blocks of fifty questions simulates the examination experience

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Symptoms include poor growth, megaloblastic anemia, and orate crystals in urine. Treatment involves cystidine or uridine to bypass this step in pyrimidine synthesis and also to negatively downregulate orotic acid production. Answer E is incorrect. A congenital deficiency of phenylalanine hydroxylase causes phenylketonuria. This enzyme converts phenylalanine to tyrosine, and a deficit of this enzyme leads to a deficiency of tyrosine and a build-up of phenylketones in the urine. It is associated with mental retardation and with the presence of phenylketones in the urine (which do not classically turn black upon standing).

A1-Antitrypsin deficiency is characterized by low levels of a protease inhibitor. This leads to elevated activity of the protease elastase and increased destruction of elastin. Answer C is incorrect. Mutations in the tumor suppressor gene p53 lead to uncontrolled cellular proliferation. Such mutations are commonly seen in the lung cancers associated with smoking (small cell and squamous cell), and they have been found in many non-small cell types. This patient’s history and x-ray findings do not suggest cancer.

Wernicke-Korsakoff syndrome, caused by a water-soluble vitamin deficiency, is suspected. Which of the following conditions is also a result of a water-soluble vitamin deficiency? A term child is delivered by spontaneous vaginal delivery without complications. Upon physical examination the child has bilateral hip dislocations, restricted movement in shoulder and elbow joints, and coarse facial features. Laboratory studies show that the activities of b-hexosaminidase, iduronate sulfatase, and arylsulfatase A are deficient in cultured fibroblasts, but are 20 times normal in the patient’s serum.

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