Eddie Elephant

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Thus, one possible explanation for the observed HLA associations with HIV disease outcome could be that the specific HIV epitopes presented by different HLA-B molecules have an important bearing on the effectiveness of the CD8+ T-cell response. A common feature of the immunodominant epitopes presented by HLA alleles that are associated with slow HIV disease progression, HLA-B*27/*57/*5801/*8101, is that these are all within the highly abundant and conserved Gag capsid (p24) protein [45, 57–61].

Group B streptococcal disease in infants: a case control study. Archives of Disease in Childhood. 2009;94:674–80. 26. Merenstein GB. Neonatal sepsis. Current Opinion in Infectious Diseases. 1992;5:553–7. 27. Johnson CE, Whitwell JK, Pethe K, Saxena K, Super DM. Term newborns who are at risk for sepsis: are lumbar punctures necessary? Pediatrics. 1997;99:E10. 28. Fielkow S, Reuter S, Gotoff SP. Cerebrospinal fluid examination in symptom-free infants with risk factors for infection. J Pediatr. 1991;119:971–3.

An important finding was that neck flexion did not increase the size of the interspinous space. Because neck flexion is associated with desaturation in the neonatal setting this provides further evidence that it should be avoided [39]. 1 Empiric Antibiotics Once bacterial meningitis is suspected, there should be no delay in starting appropriate empiric antibiotics. This requires knowledge of the likely pathogens and their antibiotic susceptibilities. In most developed countries, group B streptococcus and E.

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