Diagnosis and Treatment of Genitourinary Malignancies by Ronald K. Ross (auth.), Kenneth J. Pienta (eds.)

By Ronald K. Ross (auth.), Kenneth J. Pienta (eds.)

The box of genito-urinary oncology is speedily evolving at nearly each point. major advances were made in our knowing of the molecular and mobile occasions which give a contribution to the new release of GU malignancies. even as, related advances were made within the scientific enviornment that have superior the prognosis and therapy of urologic cancers.
This quantity makes an attempt to summarize these advances which so much influence us as clinicians, and has been divided into 3 sections. part One, `Diagnostic advances: using molecular medication within the prognosis and diagnosis of GU malignancies', info how epidemiologic experiences and new molecular options are impacting our skill to diagnose and deal with GU tumors. part , `Surgical and radiation advances', info the new significant advances within the therapy of organ-confined cancers. part 3, `Medical advances', addresses significant concerns within the remedy of metastatic ailment. This quantity will function a compendium of the advances, either on the uncomplicated technology and medical degrees, that are presently impacting training oncologists and urologists.

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34. Steinbach F, Novick AC, Shoskes D (1994). Renal transplantation in patients with renal cell carcinoma and von Hippel-Lindau disease. Urology 44:760. 35. Walther MM, Choyke PL, Weiss G, et al. (1995). Parenchymal sparing surgery in patients with hereditary renal cell carcinoma~J Urol 153:913. 37 36. Steinbach F, Novick AC, Zincke H, et al. (1995). Treatment of renal cell carcinoma in von Hippel-Lindau disease: a multicenter study. J Urol 153:1995. 37. Nelson 18, Oyasu R. Dalton DP (1994). The clinical and pathologic manifestations of renal tumors in von Hippel-Lindau disease.

No intervention is necessary for asymptomatic cysts or cystadenomas; however, pancreatectomy must be considered for solid tumors of the pancreas. Epididymal and broad ligament cystadenomas. Although unilateral epididymal cysts occur in nearly one quarter of the general population [65], cysts and A Figure 2-6. Clinical heterogeneity of VHL manifestations. A. Screening abdominal CT with IV contrast enhancement of an asymptomatic 16-year-old patient. Note extensive cysts of the pancreas, with normal kidneys.

Monoclonal antibody MIB1 and polyclonal antibody Ki67 recognize parts of the Ki67 antigen that survive formalin fixation. KiS1 recognizes a cell-cycle-associated antigen expressed during DNA synthesis. Currently, there is a wealth of other cell-cycle-associated antigens under development [20]. Apoptosis (programmed cell death) can be measured by the detection of fragmented DNA with the TUNEL assay (terminal deoxyribonucleotidyltransferase-mediated dUTP-digoxigenin nick end labeling). However, this assay is not specific for apoptosis and will also stain necrosis.

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