By Philip T. Cagle MD, Timothy C. Allen MD JD, Roberto Barrios MD, Carlos Bedrossian MD, Megan K. Dishop MD, Armando Fraire MD, Abida K. Haque MD, Keith M. Kerr MD, Alvaro C. Laga MD, Mary L. Ostrowski MD, Anna Sienko MD
Prepared by means of popular specialists in pulmonary pathology, this accomplished and profusely illustrated text-atlas offers a multimodality method of the prognosis of lung disease—preparing you to stand your subsequent problem with confidence.
For the working towards pathologist, the publication presents a roadmap to swifter, extra exact analysis of lung disease...and for the guy, resident, or pupil, it really is an vital research software, excellent whilst getting ready for tests or subspecialty Board certification.
Precise analysis of lung pathology starts off here.
- Unmatched coverage addresses the whole spectrum of lung pathology—from lung melanoma and emphysema to infectious ailments and transplant-related problems—with in-depth fabric on universal, infrequent, and newly defined sickness entities.
- Detailed discussions of the gross, cytologic, and histologic gains of every disorder increase your realizing and sharpen your diagnostic skills.
- Expert authors allow you to make the most of their years of diagnostic experience.
- Over 1,100 full-color illustrations exhibit severe info from between a extensive diversity of findings, acquired utilizing the newest diagnostic modalities.
- Use of the most up-tp-date category schemes in lung disease assures you of the most up-tp-date, exact guidelines.
- Special topics deal with the demanding situations of drug-related lung difficulties, forensic pathology, pediatric pulmonary pathology, and more.
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Extra resources for Color atlas and text of pulmonary pathology
Histologic Features: ■ Reactive changes include atypia and mitoses in reactive seromucinous bronchial glands that may suggest malignancy; goblet cell metaplasia and squamous metaplasia of bronchial and bronchiolar epithelium (see Chapter 14); collections of macrophages containing smoker’s pigment as a result of smoking and around areas of fibrosis or mass lesions; type 2 pneumocyte hyperplasia; and mesothelial cell hyperplasia. ■ Nonspecific findings include peribronchial anchoring fibers and nonspecific focal peribronchial scars that may suggest interstitial fibrosis; large, dark, multilobed megakaryocytes within alveolar capillaries that may resemble viral inclusions or malignant cells; intraalveolar fibrin that may mimic fungal hyphae; Gomori methenamine-silver (GMS) staining of mucin (which may suggest fungus when round foci of apical mucin in goblet cells or seromucinous glands are stained); collagen is often birefringent on polarized light and should not be confused with foreign material.
A variety of noncellular structures may be incidentally observed in lung tissue samples. They may be produced endogenously in both pathologic and nonpathologic conditions or may be exogenous materials inhaled into the lungs. The exogenous and endogenous materials associated with specific disease conditions are discussed elsewhere, including Chapters 35, 55, 59, 64, 78, 79, 80, 85, 125, 126, and 127. Histologic Features: ■ ■ ■ ■ ■ Corpora amylacea (30–200 m) are round to oval endogenous concretions arranged in concentric layers; radiating lines may cross the more prominent concentric laminations; they may have a black or birefringent central core; typically pale pink on hematoxylin and eosin (H&E) stain: found in alveoli and alveolar walls; may be surrounded by a rim of macrophages; periodic acid-Schiff (PAS) positive (stain bright magenta); composed of glycoproteins and lack iron and calcium; no known clinical significance but may form around irritating inhaled particles or secretions.
Both the visceral and parietal pleurae carry lymphatics and blood vessels. 1 Visceral pleura shows a connective tissue layer overlying alveolar parenchyma and is lined on the outer pleural surface by a single layer of simple flat mesothelial cells. 2 Pleura shows the thickened media of a vessel cut in cross section (which should not be confused with nerve or granuloma) and smaller blood vessels and lymphatics. Cagle_Sec01_ch1-6_001-018 8/9/04 9:58 AM Page 17 Normal Cytology of the Lung and Pleura .