CC Chemokine of Molluscum Contagiosum Virus by McFadden G., Moyer R.

By McFadden G., Moyer R.

Virus-encoded participants of the chemokine superfamily of ligands were stumbled on within the genomes of convinced poxviruses and herpesviruses. The MC148R gene of molluscum contagiosum virus, a human-specific poxvirus that induces benign epidermis lesions which could turn into clinically severe in immunocompromised sufferers, encodes for amemberof theCCchemokinesuperfamily that could antagonize the actions of a number of human CC chemokines confirmed. The MC148R protein lacks yes amino acid motifs on the N-terminus which are believed to be required for signaling from cognate chemokine receptors, and this option is thought to be very important for its job as a CC chemokine antagonist.

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21) T (V ) = (1 − V G0 )−1 V = (V −1 − G0 )−1 . 22) with the formal solution: One can also write this in terms of the Green’s functions: G = G0 + G0 V G −1 = (G−1 0 −V) = G0 + G0 T (V )G0 . 20) where each V i is one of the cell potentials. 24) j i i i Vj + .... V i G0 Vi+ V i] = T = T[ By grouping all terms containing only one cell potential, we can rewrite the equation above in terms of the cell t-matrices: ti + V i] = T[ i i tj + . . 26) i i,j and it can be shown by iteration that the T ij s satisfy: T ij = ti δij + ti G0 T kj .

It is given by (suppressing the integrations): T ij = tˆi δij + tˆi G0 tˆj (1 − δij ) + tˆi G0 tˆk G0 tˆj + . . 8) k=i which can be found by iteration. Although we have assumed point scatterers so far, all results are valid for any geometrical form of the scatterers as long as they do not overlap [39]. So far, we have kept everything time dependent, since it is very nice to think in terms of moving waves. In condensed matter theory, many phenomena are time independent, and this can of course also be treated with scattering theory.

44) where ΩIR is the interstitial at R and Ωov R is the overlapping part of the potential cell at R. This means that we need the full potential for parts of the unit cell, but since the calculation of this is very time consuming, we here use the SCA. 45) 3 where WR = 4π(wR − s3R )/3. Both the spherical part of the muffin-tin potential and the muffin-tin constant are thus given by the spherical average of the full potential. Now it is just to construct this average potential. 46) R where ZR is the protonic charge at R.

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