Atlas of Clinical Sleep Medicine: Expert consult - Online by Meir H. Kryger MD

By Meir H. Kryger MD

From Meir H. Kryger, MD, the editor of the definitive source in sleep, rules and perform of Sleep medication, comes the Atlas of scientific Sleep drugs. This hugely illustrated atlas will give you an excellent visible relief to the main entire, authoritative, and up to date info for diagnosing and treating grownup and pediatric sufferers with sleep problems. it's the first atlas that makes use of the hot scoring ideas, and reports tips to use the hot AASM scoring guide that is helping you ranking, interpret, and diagnose sleep problems. each one bankruptcy information the physiologic, scientific, morphologic, and investigational elements of the total variety of sleep problems you come across in daily perform. medical info is gifted in an easy-to-understand kind, and the mixing of colour deals elevated visible tips. Plus, with specialist seek advice performance, you should have easy accessibility to the total textual content on-line, in addition to the entire book's illustrations, greater than 20 movies of sufferer interviews, over forty sleep lab movies, and 2 hundred plus polysomnogram fragments at expertconsult.com.

  • Includes entry to the full-text on-line at expertconsult.com, in addition to all the book's illustrations, greater than 20 video clips of sufferer interviews, together with narcolepsy and stressed leg syndrome, over forty sleep lab video clips, together with obstructive sleep apnea and respiration ailments, and 2 hundred plus polysomnogram fragments.
  • Uses the recent scoring principles, and stories tips to use the hot AASM scoring guide that is helping you ranking, interpret, and diagnose sleep disorders.
  • Covers the whole diversity of sleep problems so that you can diagnose any you spot.
  • Features discussions of pediatric stipulations resembling pediatric congenital illnesses so that you can larger diagnose and deal with this precise crew.
  • Contains a wealth of high quality polysomnograms taken from the most recent machines utilized by associations round the world.
  • Emphasizes pharmacology and contains information regarding the most recent medicinal drugs to be had in addition to these in medical trials that can assist you make sure the simplest and latest drug therapy.
  • Uses photographs and drawings to successfully describe the body structure of sleep drugs to aid make tough suggestions more straightforward to know.
  • Offers a full-color compendium that mixes the body structure of sleep with the suitable findings to give an entire photo of ways sleep impacts each one physique system.
  • Uses a constant, easy-to-follow bankruptcy layout that makes reference easy.

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Extra resources for Atlas of Clinical Sleep Medicine: Expert consult - Online and Print, 1e

Example text

In addition to its ability to synchronize circadian rhythms, melatonin can also promote sleep. Integrated timing information from the SCN is transmitted to sleep-wake centers in the brain. Thus, the sleepwake cycle is generated by a complex interaction of endogenous circadian and sleep processes, as well as by social and environmental factors. 2-3. There are at least two variables that seem to play a role in the regulation of the timing of sleep. First is the homeostatic sleep drive, which increases the longer a person is awake.

2-1. The genetic mechanism of the circadian clock is similar in many species, from prokaryotic bacteria to fruit flies to mammals. The key mechanism appears to involve an exquisitely timed transcription and translation feedback loop between nuclear gene expression and their protein products. In mammals, protein dimers of PER and CRY protein bind to dimers of CLOCK and BMAL1 on the E-box for per genes and inhibit transcription of the PER and CRY genes. Reduced PER/CRY transcription to mRNAs and translation to proteins subsequently disinhibits CLOCK/BMAL1 binding to the enhancer (E)-box, which leads to renewed transcription of PER and CRY.

This was followed by the discovery at Stanford University, confirmed by Jerome Siegel’s group at UCLA, that most cases of human narcolepsy, with cataplexy and HLA-DQB1*0602 positive, are associated with a loss of hypocretin peptide in the cerebrospinal fluid and the brain (Fig. 2-38). 2005 NIH holds a second consensus conference on management of insomnia. 2007 Juliane Winkelman found through a genome-wide association that single nucleotide polymorphisms with the BTBD9, MEIS1, and MAP2K5/LBXCOR1 region are associated with RLS.

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