Apoptosis and Its Relevance to Autoimmunity by Keith B. Elkon

By Keith B. Elkon

During the last 15 years, apoptosis has turn into a dominant concentration of clinical study within the box of immunology. This book discusses the 3 significant parts of apoptosis examine: extrinsic demise receptor pathways, intrinsic cellphone dying pathways and the mechanisms liable for apoptotic mobile clearance. each one part delineates the proteins and sign transduction pathways and describes genetic adjustments that bring about autoimmune illnesses. even if so much telephone demise abnormalities were linked to systemic autoimmune problems comparable to lupus erythematosus and lymphoproliferative syndromes, it really is obvious that law of cellphone dying is usually pertinent to affliction expression in lots of organ-specific ailments resembling rheumatoid arthritis and glomerulonephritis.This quantity highlights the hot advances within the uncomplicated mechanisms of apoptosis and the applying of that wisdom to figuring out the impression of faulty apoptosis or faulty clearance of apoptotic cells at the immune functionality and the expression of illness. it's of particular curiosity to phone biologists, immunologists and clinicians.

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Extra resources for Apoptosis and Its Relevance to Autoimmunity

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J Pediatr 2000;136:682–687. Straus SE, Jaffe ES, Puck JM, et al: The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood 2001;98:194–200. Beltinger C, Bohler T, Schrappe M, Ludwig WD, Debatin KM: The role of CD95 (APO-1/ Fas) mutations in lymphoproliferative and malignant lymphatic diseases. Klin Paediatr 1998;210: 153–158. Gronbaek K, Straten PT, Ralfkiaer E, et al: Somatic Fas mutations in non-Hodgkin’s lymphoma: Association with extranodal disease and autoimmunity.

Nat Immunol 2003;4:404–409. Peter ME, Krammer PH: The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 2003;10: 26–35. Yang X, Khosravi-Far R, Baltimore D: Daxx: A novel Fas-binding protein that activates JNK and Apoptosis. Cell 1997;89:1067–1076. Stanger B, Leder P, Lee T, Kim E, Seed B: RIP: A novel protein containing a death domain that interacts with fas/APO-1(CD95) in yeast and causes cell death. Cell 1995;81:513–523. Chu K, Niu X, Williams LT: A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

100 Singer GG, Abbas AK: The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994;1:365–371. 101 Kishimoto H, Surh CD, Sprent J: A role for Fas in negative selection of thymocytes in vivo. J Exp Med 1998;187:1427–1438. Frédéric Rieux-Laucat, PhD Unité INSERM 429 Université Paris V Hôpital Necker Enfants Maladies 149, rue de Sèvres FR–75015 Paris (France) Tel. fr Rieux-Laucat 36 Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity.

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