By Richard F. Lockey, F. Lockey Richard, Samuel C. Bukantz, Jean Bousquet
Enlarged to explain greater than a decade of advances within the immunotherapy of allergic illnesses and bronchial asthma, this 3rd version comprises the newest stories at the mechanisms, manufacture, and standardization of varied allergen teams and their usage within the remedy of allergic diseasesвЂ”containing eight new chapters detailing a number of pharmacoeconomic, regulatory, production, management, and issues of safety bearing on new and rising immunotherapy ideas.
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Additional resources for Allergens and Allergen Immunotherapy
68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. Cohen and Evans Phillips EW. Relief of hay fever in intradermal injections of pollen extracts. J Am Med Assoc 1922; 79:125. Le Noir P, Richet C Jr, Renard. Skin test for anaphylaxis. Bull Soc Med Hop 1921; 45:1283 (abstr); J Am Med Assoc 77:1770. Report of the Joint Committee on Standards. J Allergy 1935; 6:408. Heidelberger M, Avery OT. The soluble specific substance of pneumococcus. J Exp Med 1924; 40:301.
60. 61. 62. 63. 64. 31 Lowdermilk RC. Hay-fever. J Am Med Assoc 1914; 63:141. Cooke RA. The treatment of hay fever by active immunization. Laryngoscope 1915; 25:108. Schloss O. A case of allergy to common foods. Am J Dis Child 1912; 3:341. Walker IC. Studies on the sensitization of patients with bronchial asthma (Study series III–XXXVI). J Med Res 1917:35–37. Wodehouse RP. Immunochemical study and immunochemistry of protein series. J Immunol 1917; 11:VI. cat hair, 227; VII. horse dander, 237; VIII.
These results suggested that a similar injection technique might successfully desensitize the presumed human counterpart disorders of asthma and hay fever. Investigational pursuit of active immunization for hay fever was soon begun in the laboratories of the Inoculation Department at St. Mary’s Hospital in London. ” Wright’s enthusiasm was reflected in his frequent prediction that “the physician of the future may yet become an immunisator” (28). Noon (Fig. ” To accomplish active immunization, he initiated clinical trials in 1910 with a series of subcutaneous injections of dosages of pollen extracts calculated on a pollen-derived weight basis (Noon unit), and thus introduced preseasonal immunotherapy.