Advances in Biochemical Engineering, Volume 003 by T.K. Ghose ,A. Fiechter, N.Blakebrough

By T.K. Ghose ,A. Fiechter, N.Blakebrough

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Some basic data on this linkage can be obtained also by the simplified method of crossing auxotrophic drug-resistant mutants and prototrophic drug-sensitive mutants belonging to different metabolic groups. ,so, ...... IRec°mbinantsl I Segregants from 1 heteroclones l Fig. 7. , 1973a). In each step the biosynthetic activity should be proved in all the strains obtained recombinants (Mindlin et aL, 1961b, 1966, 1968; Boronin and Mindlin, 1971). In the course of the mapping experiments with S. rimosus (Ala~evi6, 1969a) the segregation of OTC production was also examined.

The above facts also indicate that one cannot draw a precise boundary between primary and secondary metabolism of natural compound producers. It is likely that a single general common metabolic pattern exists and that various regulatory mechanisms determine the flow of intermediates and the intensity of the individual competing metabolic pathways. The production activity is then the result of interaction of the various control levels. From this point of view then the terms secondary metabolism and secondary metabolite seem to be redundant.

1971 ; Ho~filek and Van~k, 1973) it appears that the phenotypic expression of many mutants seemingly blocked in the secondary metabolic pathway can be actually due to the genetic changes in primary metabolism responsible for the supply of a specific precursor (acetylCoA) to secondary biosynthesis. This assumption is in agreement with the conclusions expressed by Deli6 et al. (1969) on the basis of cosynthetic experiments. g. , 1971) suggest the possibility of multiple-point mutations, affecting simultaneously a greater number of biochemical functions of the organism.

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