ABC of Asthma by John Rees

By John Rees

Bronchial asthma is a typical with expanding occurrence. This re-creation of the very hot ABC of Asthma has been completely revised near to the newest British Thoracic Society directions at the administration of bronchial asthma in young children and adults. It covers the advances in perform and techniques, with a brand new emphasis on supply platforms, self-dose evaluation and supply of care with assorted pharmacological ways.

The ABC of Asthma is a concise, up to date evaluate of all elements of bronchial asthma and includes two new chapters focussing on GP perform matters including clinical administration and organisation of bronchial asthma care. it really is excellent for GPs, junior medical professionals and clinical scholars, nurses, and an individual facing the remedy of bronchial asthma in childrens and adults.

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CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J Appl Physiol. 2004;97:2310–21.  Anatomically-based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol. 2005;99:731–8.  The arterial load in pulmonary hypertension. Eur Respir Rev. 2010;117:197–203.  Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension.  2008;29: 1688–95. 48. Tawhai MH, Clark AR, Burrowes KS.

2012;186(8):780–9. 85.  Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005;38:1949–71. F. Chen KD, Li YS, Kim M, et al. Mechanotransduction in response to shear stress: roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem. 1999;274:18393–400.  Molecular mechanisms of the vascular responses to haemodynamic forces. J Intern Med. 2006;259:381–92. 88.  Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress.

More recently, Benfluorex, a benzoate ester that shares structural and pharmacologic characteristics with dexfenfluramine and fenfluramine, has also been associated with the development of PAH. The active and common metabolite of each of these molecules is norfenfluramine, which itself has a chemical structure similar to that of the amphetamines. Given its pharmacological properties, benfluorex would be expected to have similar toxic effects to the fenfluramine derivatives [21, 22]. An outbreak of valvular heart disease and/or PAH induced by benfluorex use was identified by the French PH network from June 1999 to March 2011 and included 85 cases of PAH.

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